Interaction Between Glucocorticoid Receptors and FKBP5 in Regulating Neurotransmission of the Hippocampus

Seungjae Zhang, Myunghyun Cheon,Hoyong Park,Taejoon Kim,ChiHye Chung

Neuroscience（2022）

引用 2|浏览7

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摘要

•FKBP5 deficiency did not change spontaneous transmission but the spontaneous activity is altered towards less inhibition.•GR activation in the hippocampus increased AMPAR/NMDAR ratio and the PPR of eIPSCs.•FKBP5 loss blocks the effect of GR activation on both excitatory and inhibitory synapses.•FKBP5 is a key mediator in GR action in the hippocampus.

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关键词

A/N ratio,CORT,E/I,eCB,eE(I)PSC,Fkbp5 −/−,FKBP5,GR,KO,mE(I)PSC,mPFC,PFC,PPR,RI,sE(I)PSC,WT

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