A pH-sensitive liposome formulation of a peptidomimetic-Dox conjugate for targeting HER2 + cancer

Jafrin Jobayer Sonju,Achyut Dahal,Sitanshu S Singh,Xin Gu,William D Johnson,Chandra Mohan Reddy Muthumula,Sharon A Meyer,Seetharama D Jois

International Journal of Pharmaceutics（2022）

引用 12|浏览11

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摘要

•A pH-sensitive liposome containing peptidomimetic-doxorubicin conjugate was developed.•The formulation was able to release more the drug conjugate at pH 6.5 comapred to 7.4.•The cellular uptake of the conjugate was high in HER2 positive cancer cells.•The formulation exhibited anticancer activity in 3D tumor spheroid model.•The formulation was able to suppress the NSCLC tumor in mice model.

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关键词

pH-sensitive liposome,Doxorubicin,Peptide conjugate,Lung cancer,HER2

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