Propagation of TDP-43 proteinopathy in neurodegenerative disorders.

Rachel Keszycki,Pouya Jamshidi,Allegra Kawles,Grace Minogue,Margaret E Flanagan,Colleen R Zaccard,M Marsel Mesulam,Tamar Gefen,Changiz Geula

Neural regeneration research（2022）

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摘要

Neu rodegenerative disorders are characterized by disruptions to neuronal function and circuitry,leading to a variety of clinical syndromes depending on the affected neuroanatomic regions（Geula,1998）.Many proteinopathies implicated in neurodegenerative diseases are characterized by the pathologic accumulation of proteins into inclusions that are initially deposited in specific areas of the brain and spread widely with disease progression,

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