A potential biomarker of preclinical Alzheimer’s disease: The olfactory dysfunction and its pathogenesis-based neural circuitry impairments

Yan Yan,Ailikemu Aierken,Chunjian Wang,Da Song,Junjun Ni,Zhe Wang,Zhenzhen Quan,Hong Qing

Neuroscience & Biobehavioral Reviews（2022）

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摘要

•Olfactory identification dysfunction is considered as a preclinical symptom in AD•The OB and PCx- related neural networks are impaired in the olfaction system of AD•Aberrant network oscillations and synaptic plasticity damages might lead to the degeneration of the OB and PCx- related neural networks in AD.

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关键词

Olfactory dysfunction,Alzheimer’s disease,Neural networks,Neuronal oscillation,Synaptic plasticity

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