Pilose antler polypeptides promote chemosensitization and T-cell infiltration of triple-negative breast cancer

Mohan Li,Kexin Zheng,Shiliang Ma,Pengpeng Hu,Bo Yuan,Xiqing Yue,Qilong Li

Journal of Functional Foods（2021）

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摘要

•Water-soluble polypeptides from pilose antler (PAWPs) enhance chemosensitization.•The PAWPs reduce the side effects of neoadjuvant chemotherapy (NAC).•NAC + PAWPs promotes T cell infiltration and improves T cell populations.•NAC + PAWPs via TGF-β1-SMAD3 signaling pathway to reduce CAFs infiltration.

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关键词

Triple-negative breast cancer,Neoadjuvant chemotherapy,Tumor microenvironment,Cancer-associated fibroblasts,Immunocyte infiltration

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