Arecanut (Areca catechu L.) seed polyphenol improves osteoporosis via gut-serotonin mediated Wnt/β-catenin pathway in ovariectomized rats

Keke Meng,Fengfeng Mei,Lehui Zhu,Qingying Xiang,Zhangyan Quan,Feibing Pan,Guanghua Xia,Xuanri Shen,Yonghuan Yun,Chenghui Zhang,Qiuping Zhong,Haiming Chen

Journal of Functional Foods（2021）

引用 14|浏览4

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摘要

•Arecanut seed polyphenol (ACP) ameliorated osteoporosis in ovariectomized rats.•ACP induced an altered serum metabolism in ovariectomized rats.•ACP upregulated Lrp5 via liver fat metabolism marked by the decreased 7-Ketodeoxycholic acid.•ACP downregulated 5-HT via altering tryptophan metabolism marked by decreased indole.

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关键词

Arecanut (Areca catechu L.) seed polyphenol,Serotonin,Serum metabolic,Osteoporosis,Bone formation

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