Refractometric Sensing With Plasmonic Tilted Bragg Gratings In Different Fiber Types

Tilted fiber Bragg gratings (TFBGs) coupled to the surface plasmon resonance (SPR) phenomenon represent a powerful sensing solution especially for biodetection purposes. Indeed, the excitation of plasmonic waves at the metal-coated surface of the sensor brings a significant improvement in terms of surface sensitivity. Until now, most of experimental results involving SPR have been obtained by using TFBGs inscribed in standard single-mode optical fibers (SMF), which requires the use of a polarizer to select the right state of polarization for plasmonic excitation. Investigations for the development of even more sensitive or robust sensing tools remain a topic of current interest. In this study, the bulk and surface refractometric sensitivities of plasmonic TFBGs photo-inscribed in multimode fiber (MMF) are compared to the one of standard SMF. Gold-coated TFBG in SMF exhibits a sensitivity value of similar to 102 nm/RIU. Plasmonic MMF TFBGs are more sensitive with a value of similar to 124 nm/RIU (enhancement of similar to 22 %) and open the way to multiplexing thanks to the narrowness of their spectral response. Surface refractometry was also assessed through HER2 bioassays (Human Epidermal Growth Factor Receptor-2), a breast cancer biomarker. For that purpose, aptasensors based on antiHER2 aptamers were developed and tested by using these two fiber types Similar surface sensitivities were obtained for both fiber types.