Long-Term Bowel And Urinary Health-Related Quality Of Life After Primary And Salvage Radiation Treatment For Prostate Cancer: Results From The Capsure Registry

You have accessJournal of UrologyProstate Cancer: Localized: Radiation Therapy (PD08)1 Sep 2021PD08-10 LONG-TERM BOWEL AND URINARY HEALTH-RELATED QUALITY OF LIFE AFTER PRIMARY AND SALVAGE RADIATION TREATMENT FOR PROSTATE CANCER: RESULTS FROM THE CaPSURE REGISTRY Avi S Baskin, Peter E Lonergan, Scott A Greenberg, Osama Mohamad, Samuel L Washington, Shoujun Zhao, Janet E Cowan, Jeanette M Broering, Matthew Cooperberg, Peter R Carroll, and Benjamin N Breyer Avi S BaskinAvi S Baskin More articles by this author , Peter E LonerganPeter E Lonergan More articles by this author , Scott A GreenbergScott A Greenberg More articles by this author , Osama MohamadOsama Mohamad More articles by this author , Samuel L WashingtonSamuel L Washington More articles by this author , Shoujun ZhaoShoujun Zhao More articles by this author , Janet E CowanJanet E Cowan More articles by this author , Jeanette M BroeringJeanette M Broering More articles by this author , Matthew CooperbergMatthew Cooperberg More articles by this author , Peter R CarrollPeter R Carroll More articles by this author , and Benjamin N BreyerBenjamin N Breyer More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001976.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Radiotherapy (RT) for prostate cancer are associated with distinct treatment-related morbidity, primarily in domains of urinary and bowel health-related quality of life (HRQOL). However, few studies have reported on the long-term HRQOL after primary and salvage radiation treatment for prostate cancer. Therefore, we sought to report on the long-term HRQOL outcomes from a nationwide, longitudinal prostate cancer registry. METHODS: We identified men diagnosed with prostate cancer and treated with primary EBRT and also radical prostatectomy (RP) followed by adjuvant/salvage EBRT and from the UCSF Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) registry covering primarily community-based US urologic practices. The University of California, Los Angeles (UCLA), Prostate Cancer Index (PCI) was used to measure urinary and bowel function which yield a score of 0-100, with higher scores denoting better function. Self-reported questionnaires were completed at enrollment and every 6 to 12 months. RESULTS: In total, 2,841 men underwent primary RT with 2,170 (76.4%) and 671 (23.6%) had adjuvant/salvage RT. Median follow-up was 8.3 years (IQR 4.7-13.2). At enrollment, the mean (±SD) urinary function score was 90.9 (±13.6) in the primary RT group and 74.5 (±24.4) in the salvage RT group. The mean bowel function score was 86.6 (±13.7) in the primary RT group and 87.2 (±15.8) in those mean treated with salvage RT. At 12 years, the mean urinary function score decreased to 85.4 (± 20.2) and 67.4 (±28.4) in the primary and salvage RT groups respectively. At 12 years, the mean bowel function score was unchanged in the primary RT group (86.5±10.5) and reduced to 84.4 (±20.4) in the salvage RT group. CONCLUSIONS: Long term decline in HRQOL is observed in urinary function to a greater extent in salvage RT compared to primary RT, whereas changes in bowel function is not as pronounced. These findings are helpful regarding shared decision making for men being treated with RT for prostate cancer. Source of Funding: UCSF Goldberg-Benioff Program in Cancer Translational Biology © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e117-e117 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Avi S Baskin More articles by this author Peter E Lonergan More articles by this author Scott A Greenberg More articles by this author Osama Mohamad More articles by this author Samuel L Washington More articles by this author Shoujun Zhao More articles by this author Janet E Cowan More articles by this author Jeanette M Broering More articles by this author Matthew Cooperberg More articles by this author Peter R Carroll More articles by this author Benjamin N Breyer More articles by this author Expand All Advertisement Loading ...