Diagnosis of Bipolar Disease Using Correlation-Based Feature Selection with Different Classification Methods

Three-Dimensional Magnetic Resonance Imaging (3D-MRI) and Computer-Aided Detection (CAD) have been widely studied in the detection of bipolar disorder (BD). In this study, the structural alterations at the grey matter (GM) and white matter (WM) of BD subjects versus healthy controls (HCs) have been compared using Voxel-Based Morphometry (VBM). In order to obtain 3D GM and WM masks, the two sample ttest method and total intracranial volumes of BD and HC as a covariate have been utilized. In addition to analyzing effects of GM and WM tissue maps separately in the detection of BD, impacts of both GM and WM ones are studied by concatenating them ın a matrix. The correlation-based feature selection (CFS) feature ranking method is applied to the obtained 3D masks to rank the features, the number of selected top-ranked features are determined using a Fisher criterion (FC) approach, and different classification algorithms are used to classify BD apart from HCs. In this study, 26 BDs and 38 HCs data are used. The experimental results indicate that the classification accuracy of Naive Bayes outperforms the other four classification algorithms used in this study. Additionally, concatenation of GM and WM tissue maps enhances the classification performances of using GM-only and WM-only ones. The classification accuracies obtained for GM, WM, and their concatenation are 72.92%, 78.33%, and 80.00% respectively.