Resveratrol Inhibits Il-1 Beta, Il-18, And Icam-1 In A Nasopharyngeal Carcinoma Model

Objective: The current study aimed to examine the effects of resveratrol (RES) on interleukin-1 beta (L-1 beta), interleukin-1 (IL-18), and intercellular cell adhesion molecule-1 (ICAM-1) in a nasopharyngeal carcinoma nude mice model. Methods: Nasopharyngeal carcinoma was modeled in the experimental group. A total of 80 male nude mice were randomly divided into experimental group A, experimental group B, control group A, and control group B, with 20 in each group. RES injections were performed in experimental group A and control group A, respectively. The same amount of carboxymethyl cellulose sodium in saline was injected in experimental group B and control group B. Five nude mice in each of the 4 groups were killed by neck fractures at T1, 3 days (72), 5 days (T3), and 7 days (T4) before injections, respectively. Blood and cancer tissues of the nude mice were obtained. Expression levels of ICAM-1 and IL-18 in cancer tissues, as well as serum IL-1 beta, were detected via enzyme-linked immunosorbent assays (ELISA). Results: There were no significant differences in IL-1 beta, IL-18, and ICAM-1 between control group A and control group B at T1, T2, T3, and T4 (P > 0.050). At T2, T3, and T4, serum IL-1 beta and IL-18 levels, as well as ICAM-1 expression levels, in cancer tissues of experimental group B were significantly lower than those in the experimental group A (P < 0.050). IL-1 beta, IL-18, and ICAM-1 in experimental group A increased with time (P < 0.050). IL-1 beta IL-18, and ICAM-1 in the experimental group B decreased with time (P < 0.050). Conclusion: RES can inhibit levels of IL-1 beta, IL-18, and ICAM-1 in nasopharyngeal carcinoma.