Data Note: Monash DaCRA fPET-fMRI: A DAtaset for Comparison of Radiotracer Administration for high temporal resolution functional FDG-PET

Background ‘Functional’ [18F]-fluorodeoxyglucose positron emission tomography (FDG- f PET) is a new approach for measuring glucose uptake in the human brain. The goal of FDG-fPET is to maintain a constant plasma supply of radioactive FDG in order to track, with high temporal resolution, the dynamic uptake of glucose during neuronal activity that occurs in response to a task or at rest. FDG-fPET has most often been applied in simultaneous BOLD-fMRI/FDG-fPET (blood oxygenation level dependent functional MRI fluorodeoxyglucose functional positron emission tomography) imaging. BOLD-fMRI/FDG-fPET provides the capability to image the two primary sources of energetic dynamics in the brain, the cerebrovascular haemodynamic response and cerebral glucose uptake. Findings In this Data Note, we describe an open access dataset, Monash DaCRA fPET-fMRI, which contrasts three radiotracer administration protocols for FDG-fPET: bolus, constant infusion, and hybrid bolus/infusion. Participants (n=5 in each group) were randomly assigned to each radiotracer administration protocol and underwent simultaneous BOLD-fMRI/FDG-fPET scanning while viewing a flickering checkerboard. The Bolus group received the full FDG dose in a standard bolus administration; the Infusion group received the full FDG dose as a slow infusion over the duration of the scan, and the Bolus-Infusion group received 50% of the FDG dose as bolus and 50% as constant infusion. We validate the dataset by contrasting plasma radioactivity, grey matter mean uptake, and task-related activity in the visual cortex. Conclusions The Monash DaCRA fPET-fMRI dataset provides significant re-use value for researchers interested in the comparison of signal dynamics in fPET, and its relationship with fMRI task-evoked activity. ### Competing Interest Statement Siemens Healthineers contributed financial support to the ARC Linkage Project held by GFE, SDJ & ZC. Other authors have no competing or conflicting interests * BIDS : Brain imaging data structure BOLD-fMRI/FDG-fPET : Blood oxygenation level dependent functional magnetic resonance imaging [18F]-fluorodeoxyglucose functional positron emission tomography DaCRA : Dataset for comparison of radiotracer administraion EPI : Echo planar images FDG : [18F]-fluorodeoxyglucose FDG- f PET : [18F]-fluorodeoxyglucose functional positron emission tomographer FDG-PET : [18F]-fluorodeoxyglucose positron emission tomography FLAIR : Fluid attenuation inversion recovery fMRI : Functional magnetic resonance imaging FOV : Field of view fPET : Functional positron emission tomography fPET-fMRI : Simultaneous functional positron emission tomography functional magnetic resonance imaging GLM : General linear model ICA : Independent component analysis ID : Identifier MPRAGE : Magnetisation prepared rapid gradient echo MRI : Magnetic resonance imaging OP-OSEM : Ordinary Poisson ordered subset expectation maximisation P-A : Posterior-anterior PseudoCT : Pseudo computed tomography ROI : Region of interest SWI : Susceptibility weighted imaging TA : Acquisition time TE : Echo time TR : Repetition time UTE : Ultrashort echo time