Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis

Nuria Pell,Ester Garcia-Pras,Javier Gallego,Salvador Naranjo-Suarez,Alexandra Balvey,Clara Suñer,Marcos Fernandez-Alfara,Veronica Chanes, Julia Carbo,Marta Ramirez-Pedraza,Oscar Reina,Louise Thingholm,Corinna Bang,Malte Rühlemann,Andre Franke,Robert Schierwagen, Karl P Rheinwalt,Jonel Trebicka,Raul Mendez,Mercedes Fernandez

Molecular Metabolism（2021）

引用 7|浏览17

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摘要

•CPEB4 expression is elevated in adipose tissue from obese patients and rodents.•CPEB4 overexpression is required for the abnormal obesity-associated phenotype.•Targeting CPEB4 reduces predisposition to diet-induced obesity.•Targeting CPEB4 alleviates obesity-associated microbiome dysbiosis.•CPEB4 is an attractive therapeutic target for treating obesity and its sequelae.

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关键词

Obesity,Translation,RNA-Binding proteins,Adipose tissue,Microbiome dysbiosis

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