Mitigated Motor Function Impairment by Enhanced Delivery of Edaravone via Ultrasound with Microbubbles in a Transgenic Mice Model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a prototypical neurodegenerative disease featured by progressive degeneration and extensive loss of upper and lower motor neurons. As a free radical scavenger, edaravone (EDA) has been proven to exert neuroprotective effects. In this study, the delivery of EDA was enhanced by low-intensity focused ultrasound combined with microbubbles (FUS/MB+EDA) in a transg...