Apigenin-oxymatrine binary co-amorphous mixture: Enhanced solubility, bioavailability, and anti-inflammatory effect

•First reported apigenin’s co-amorphous formulation for potential application in food.•Co-amorphous system enhanced solubility, bioavailability and bioactivity of apigenin.•Functional natural product was the co-former for co-amorphous with great food value.•The study provided a reliable strategy to improve the bioavailability of flavonoids.