Chronic aryl hydrocarbon receptor activity phenocopies smoking-induced skeletal muscle impairment.

Trace Thome,Kayla Miguez,Alexander J Willms,Sarah K Burke,Vijayendran Chandran,Angela R de Souza,Liam F Fitzgerald,Carolyn Baglole,Maria-Eleni Anagnostou,Jean Bourbeau,R Thomas Jagoe,Jose A Morais,Yana Goddard,Tanja Taivassalo,Terence E Ryan,Russell T Hepple

Journal of cachexia, sarcopenia and muscle（2022）

引用 17|浏览12

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摘要

These results establish that chronic AHR activity, as occurs in smokers, phenocopies the atrophy, mitochondrial impairment, and neuromuscular junction degeneration caused by chronic tobacco smoke exposure.

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关键词

Cachexia,Neuromuscular junction,Sarcopenia,Smoking

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