GEMBS – high through-put processing for DNA methylation data from Whole Genome Bisulfite Sequencing (WGBS)

Angelika Merkel,Marcos Fernández-Callejo,Eloi Casals,Santiago Marco-Sola,Ronald Schuyler,Ivo G. Gut,Simon Heath

biorxiv（2017）

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摘要

DNA methylation is essential for normal embryogenesis and development in mammals and most commonly found at CpG dinucleotides. Whole genome sequencing of bisulfite converted DNA (WGBS) currently represents the gold standard for studying DNA methylation at genomic level as contrary to other

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