The History of Prostate-Specific Membrane Antigen as a Theranostic Target in Prostate Cancer: The Cornerstone Role of the Prostate Cancer Foundation
JOURNAL OF NUCLEAR MEDICINE(2022)
摘要
Prostate-specific membrane antigen (PSMA) isa credentialed imaging and therapy (theranostic) target for the detection and treatment of prostate cancer. PSMA-targeted PET imaging and molecular radio-therapy are promising evolving technologies that will improve the out-comes of prostate cancer patients. In anticipation of this new era in prostate cancer theranostics, this article will review the history of PSMA from discovery through early-and late-stage clinical trials. Since 1993, the Prostate Cancer Foundation has funded critical and foundational PSMA research that established this theranostic revolu-tion. The history and role of Prostate Cancer Foundation funding in this field will be discussed.
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关键词
theranostics, prostate cancer, PSMA, PET imaging, molecular radiotherapy
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