Erythema nodosum following the first dose of ChAdOx1-S nCoV-19 vaccine

We present a case of erythema nodosum to ChAdOx1 nCoV-19 vaccine in a 64 years old woman. The female patient complained of painful and erythematous skin lesions on both lower limbs 2 days after receiving the first dose of ChAdOx1 nCoV-19 vaccine (Figure 1). Physical examination revelead erythematous plaques on pretibial surfaces, painful on palplation and compatible with the diagnosis of erythema nodosum (EN). The patient had no comorbidities except for heterozygous factor V Leiden mutation.