Metabolite signatures of heart failure, sleep apnoea, their interaction, and outcomes in the community.

Shashwati Dutta,Desmond Li,Andy Wang, Mark Ishak,Kristina Cook,Melissa Farnham,Hasthi Dissanayake,Peter Cistulli,Imre Hunyor, Renping Liu,Ian Wilcox,Yen Chin Koay,Jean Yang,Sean Lal,John F O'Sullivan

ESC heart failure（2021）

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摘要

Energetic metabolites were associated with cardiac function; energy- and lipid-storage metabolites with LV wall thickness and mass; plasma levels of nicotine metabolite cotinine were associated with increased time spent with a sleep oxygen saturation less than 90%, a clinically significant marker of outcome, indicating a significant hazard for smokers who have sleep apnoea.

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关键词

Biomarker,Framingham,Heart failure,Lipid,Metabolite,Mortality,Sleep apnoea

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