Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease

Daniel Charissé,Guray Erus,Raymond Pomponio,Martin Gorges,Nele Schmidt,Christine Schneider,Inga Liepelt-Scarfone,Oliver Riedel,Kathrin Reetz,Jörg B Schulz,Daniela Berg,Alexander Storch,Karsten Witt,Richard Dodel,Elke Kalbe,Jan Kassubek,Rüdiger Hilker-Roggendorf,Simon Baudrexel

Neurobiology of Aging（2022）

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摘要

•Parkinson's disease (PD) is associated with advanced structural brain aging.•Brain age predicts attention and working memory deficits in PD.•Alzheimer's-like atrophy predicts memory, language and executive dysfunction in PD.•Brain age and Alzheimer's-like atrophy predict cognitive status conversion in PD.

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关键词

Brain Age,Parkinson's disease,Alzheimer's disease,Pattern classification,MRI

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