Stride: A flexible software platform for high-performance ultrasound computed tomography

•The lack of open codes for ultrasound computed tomography has hindered adoption and reproducibility.•We present Stride, an open-source Python library for modelling and solving large-scale ultrasound tomography problems.•Stride provides expressive and flexible interfaces for solving physics-constrained optimisation problems.•Through ntegration with domain-specific languages,Stride provides high-performance wave-equation solvers in CPUs and GPUs.•Out-of-the-box scaling from a local workstation to a multi-node HPC cluster is made possible through a custom actor-based parallelisation library.