Leptin counteracts hypothermia in hypothyroidism through its pyrexic effects and by stabilizing serum thyroid hormone levels

•Thyroid hormones are essential for the regulation of body temperature.•Thyroid hormone-deficient (hypothyroid) mice show distinct leptin serum concentrations in response to changes in ambient housing temperature.•High leptin serum levels confer a stimulatory effect on the hypothalamic-pituitary-thyroid axis.•High leptin serum level prevents fall in body temperature in hypothyroid mice at room temperature through its pyrexic effects.