Morphological and biochemical repercussions of Toxoplasma gondii infection in a 3D human brain neurospheres model.

Paulo Emilio Correa Leite,Juliana de Araujo Portes,Mariana Rodrigues Pereira,Fabiele Baldino Russo,Erica S Martins-Duarte,Nathalia Almeida Dos Santos,Marcia Attias,Francisco J Barrantes,Patricia Cristina Baleeiro Beltrão-Braga,Wanderley de Souza

Brain, behavior, & immunity - health（2021）

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摘要

BrainSpheres reproduce many aspects of infection in human CNS, constituting a useful model to study the neurotoxicity and neuroinflammation mediated by the parasite. In addition, these data could be important for future studies aiming at better understanding possible correlations between psychiatric disorders and human CNS infection with .

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关键词

Brain,Inflammation,Neuropsychiatric disorders,Toxoplasmosis,iPSC

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