Transcriptional and Epigenetic Regulation of Gasdermins

•The different GSDM genes have specific tissue expression patterns.•GSDM expression is modulated by environmental factors, cell stress and cytokines.•SNPs impact GSDM expression and susceptibility to asthma and IBD.•GSDM expression levels control the balance between apoptosis and pyroptosis.•Silencing of GSDM impacts tumor immunosurveillance and response to therapy.•Targeting epigenetic modifications is a promising therapeutic avenue.