Leptin promotes glycolytic metabolism to induce dendritic cells activation via STAT3-HK2 pathway

Dr Ziran Bai,Yunshan Ye,Xiaokang Ye,Bo Yuan,Yawei Tang,Jing Wei,Minli Jin,Guan Wang,Xia Li

Immunology Letters（2021）

引用 7|浏览20

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摘要

•Leptin-activated DCs promote the proliferation of PBMC and up-regulates the percentage of Th17 cells.•DCs activation by leptin depends on glycolysis.•Leptin enhances HK2 expression on DCs via STAT3 pathway.

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关键词

Leptin,Dendritic cell,Glycolysis,HK2,Th17 cell

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