Chemotherapy-induced anaphylaxis and fatal anaphylaxis in the United States: Incidence and risk factors

Drug-induced anaphylaxis (DIA) is the most common cause of fatal anaphylaxis in the United States (US) and other countries . After antibiotics and contrast agents, chemotherapeutic medications are the third leading cause of fatal DIA in the US . However, the incidence of anaphylaxis to chemotherapeutic medications is unknown . In this study we sought to analyze the incidence and risk factors of anaphylaxis secondary to chemotherapy agents in the US.