Stress-induced protein dermcidin develops diabetes targeting GLUT4/insulinviaNO/cGMP inhibition (Withdrawal of September, 2021)

Molecular-docking experiments (AUTODOCK/PATCHDOCK) decisively showed high-affinity binding of DCD to GLUT-4, insulin, and its receptor (Ectodomain1/2). Synergism of all these effects resulted in the breakdown of glucose homeostasis-machinery i.e. insulin-resistance, and further dermcidin induced NO/cGMP down-regulation in individuals under a variety of stressors.