Altered Protein Abundance and Localization Inferred from Sites of Alternative Modification by Ubiquitin and SUMO

Adi Ulman,Tal Levin,Bareket Dassa,Aaron Javitt,Assaf Kacen,Merav D Shmueli,Avital Eisenberg-Lerner,Daoud Sheban, Simon Fishllevich,Emmanuel D Levy,Yifat Merbl

Journal of Molecular Biology（2021）

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摘要

•Sites of Alternative Modifications (SAMs) are more abundant than previously appreciated.•SUMO-ubiquitin SAMs are revealed in more than 4000 proteins across the proteome.•Ubiquitin-SUMO SAM proteins have increased protein abundance and altered cyto-nuclei localization.•SAM-associated features are functionally conserved from yeast to human.

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关键词

post-translational modification (PTM),proteostasis,ubiquitin,SUMO,Ubiquitin-like (Ubl)

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