Altered network stability in progressive supranuclear palsy

David J Whiteside,P Simon Jones,Boyd C P Ghosh,Ian Coyle-Gilchrist,Alexander Gerhard,Michele T Hu,Johannes C Klein,P Nigel Leigh,Alistair Church,David J Burn,Huw R Morris,James B Rowe,Timothy Rittman

Neurobiology of Aging（2021）

引用 6|浏览11

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摘要

•We investigated network dynamics in the tauopathy progressive supranuclear palsy•Abnormal temporal properties of large-scale networks are related to phenotype•Progressive supranuclear palsy paradoxically increases frontoparietal state time•Reductions in neural signal complexity relate to altered network dynamics•Dynamic network and topological changes occur distally to primary sites of atrophy

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关键词

Progressive supranuclear palsy,Network dynamics,Hidden Markov models,Complexity

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