Traffic-related air pollution, biomarkers of metabolic dysfunction, oxidative stress, and CC16 in children
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY(2021)
摘要
Background Previous research has revealed links between air pollution exposure and metabolic syndrome in adults; however, these associations are less explored in children. Objective This study aims to investigate the association between traffic-related air pollutants (TRAP) and biomarkers of metabolic dysregulation, oxidative stress, and lung epithelial damage in children. Methods We conducted cross-sectional analyses in a sample of predominantly Latinx, low-income children ( n = 218) to examine associations between air pollutants (nitrogen dioxide (NO 2 ), nitrogen oxides (NO x ), elemental carbon, polycyclic aromatic hydrocarbons, carbon monoxide (CO), fine particulates (PM 2.5 )) and biomarkers of metabolic function (high-density lipoprotein (HDL), hemoglobin A1c (HbA1c), oxidative stress (8-isoprostane), and lung epithelial damage (club cell protein 16 (CC16)). Results HDL cholesterol showed an inverse association with NO 2 and NO x , with the strongest relationship between HDL and 3-month exposure to NO 2 (–15.4 mg/dL per IQR increase in 3-month NO 2 , 95% CI = –27.4, –3.4). 8-isoprostane showed a consistent pattern of increasing values with 1-day and 1-week exposure across all pollutants. Non-significant increases in % HbA1c were found during 1-month time frames and decreasing CC16 in 3-month exposure time frames. Conclusion Our results suggest that TRAP is significantly associated with decreased HDL cholesterol in longer-term time frames and elevated 8-isoprostane in shorter-term time frames. TRAP could have the potential to influence lifelong metabolic patterns, through metabolic effects in childhood.
更多查看译文
关键词
Traffic-related Air Pollution, Early Life Childhood Exposure, Oxidative Stress, Metabolic Dysregulation, Polycyclic Aromatic Hydrocarbons, Low-SES Populations
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要