Maternal immune activation primes deficiencies in adult hippocampal neurogenesis

Amalie C.M. Couch,Thomas Berger,Bjørn Hanger,Rugile Matuleviciute,Deepak P. Srivastava,Sandrine Thuret,Anthony C. Vernon

Brain, Behavior, and Immunity（2021）

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摘要

•Reduced AHN is linked closely with risk and resilience for psychiatric illness.•Prenatal MIA exposure reduces AHN through direct and indirect mechanisms.•We hypothesise that AHN may mediate susceptibility or resilience to MIA.•Studies in animal and human cellular models are required to test this hypothesis.

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关键词

Maternal immune activation,Prenatal insult,Hippocampus,Neurogenesis,Stress,Psychiatric illness,Neurodevelopmental disorders,Human induced pluripotent stem cells

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