Association of Protective HLA-A With HLA-B ∗ 27 Positive Ankylosing Spondylitis.

Jessika Nordin,Mats Pettersson,Lina Hultin Rosenberg,Argyri Mathioudaki,Åsa Karlsson,Eva Murén,Karolina Tandre,Lars Rönnblom,Alf Kastbom,Jan Cedergren,Per Eriksson,Peter Söderkvist,Kerstin Lindblad-Toh,Jennifer R S Meadows

Frontiers in genetics（2021）

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摘要

Population stratification allowed for a nuanced investigation into the tightly linked MHC region, revealing novel signals as well as replicating previous dependent results. This dissection of signals may help to elucidate sex biased disease predisposition and clinical progression.

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关键词

HLA allele typing,HLA-A∗24:02,HLA-B∗27 positive,ankylosing spondylitis,major histocompatibility complex,sex biased

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