Application of retention modeling in chiral method development. I. Selection of isocratic composition for preparative separation with SFC
Journal of Chromatography A(2021)
摘要
•An approach to obtain isocratic methods for preparative chiral separation presented.•The approach employs solvent-gradient theory to develop an experimental protocol.•The protocol enables an analyst to estimate separation under all isocratic conditions.•Effectiveness of the protocol in high-throughput environment demonstrated.
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关键词
Modeling,Chiral,Preparative,Isocratic,Separation,Productivity
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