Antiplatelet therapy in patients with atrial fibrillation: a systematic review and meta-analysis of randomized trials.

Alexander P Benz,Isabelle Johansson,Willem J M Dewilde,Renato D Lopes,Roxana Mehran,Samantha Sartori,Nikolaus Sarafoff,Satoshi Yasuda,William F McIntyre,Jeff S Healey,Ashkan Shoamanesh,John W Eikelboom,Stuart J Connolly

European heart journal. Cardiovascular pharmacotherapy（2022）

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摘要

In patients with AF not receiving oral anticoagulation, antiplatelet therapy modestly reduced stroke. There was a corresponding signal for harm when used on top of anticoagulation. Irrespective of background anticoagulation use, antiplatelet therapy significantly increased bleeding, moderately reduced myocardial infarction, and did not affect mortality.

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关键词

Aspirin,Atrial fibrillation,Bleeding,P2Y12 inhibitor,Stroke, Antiplatelet

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