Longipone A, A Unique Tricyclic Polyketide From The Fungus Xylaria Longipes

Longipone A (1), a novel polyketide containing a tetrahydro-anthracene core structure, was isolated from the liquid fermentation of fungus Xylaria longipes. Its structure, including absolute configuration, was determined on the basis of spectroscopic data and X-ray crystallography. A plausible biosynthesis pathway has also been proposed. This compound exhibited moderate cytotoxicity (IC50 10.3-35.2 mu M) against HL-60, A549, MCF-7 and SW480 human cancer cell lines. (C) 2021 Elsevier Ltd. All rights reserved.