Spike-based analysis of brain injured anesthetized animals undergoing closed-loop intracortical stimulation

Acquired brain injuries, such as stroke, are a major cause of long-term disability worldwide. When an injury occurs within primary motor cortex (M1) there is both a loss of descending information to the spinal cord and a disruption in the communication within and between spared regions, which can lead to hemiparesis and other motor dysfunction. Recently, activity-dependent stimulation (ADS), a clo...