Depression in multiple sclerosis: Is one approach for its management enough?

•Depression is highly prevalent and poorly-managed in persons with multiple sclerosis (MS).•There is limited evidence for the efficacy of pharmacological treatments for depression in MS.•There is weak evidence for the use behavioral treatments for depression in MS.•Currently, there is no gold-standard, single treatment for depression in MS.•Combinatory treatments may be efficacious for treating MDD and managing its consequences in MS.