Intravenous Allogeneic Multilineage-Differentiating Stress-Enduring Cells In Adults With Dystrophic Epidermolysis Bullosa: A Phase 1/2 Open-Label Study

Y. Fujita,T. Nohara,S. Takashima,K. Natsuga, M. Adachi,K. Yoshida,S. Shinkuma,T. Takeichi,H. Nakamura,O. Wada,M. Akiyama,A. Ishiko,H. Shimizu

Journal of The European Academy of Dermatology and Venereology（2021）

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摘要

Epidermolysis bullosa (EB) is a group of genodermatoses characterized by generalized blisters from mutations in the genes encoding the basement membrane zone (BMZ) proteins. The infusion of allogeneic cells such as mesenchymal stem/stromal cells (MSCs), which have intact BMZ genes, is a promising treatment.

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关键词

Muse cells,SSEA-3,clinical trial,epidermolysis bullosa,mesenchymal stem/stromal cells,multi-lineage differentiating stress-enduring cells

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