Peroxiredoxins Wear Many Hats: Factors That Fashion Their Peroxide Sensing Personalities
REDOX BIOLOGY(2021)
摘要
Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a challenge. In this review, we give a tabulated overview on what is known about human and bacterial peroxiredoxins with a focus on structure, PTMs, and protein-protein interactions. Armed with numerous cellular and atomic level experimental techniques, we look at the future and ask ourselves what is still needed to give us a clearer view on the cellular operating power of Prdxs in both stress and non-stress conditions.
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关键词
Peroxiredoxin, Redox signaling, Post-translational modification (PTM), Protein-protein interactions (PPI), Prx, Prdx
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