αA-Crystallin inhibits optic nerve astrocyte activation induced by oxygen-glucose deprivation in vitro

•We observed the inhibition of αA-crystallin in astrocyte activation in vitro.•αA-crystallin inhibited the migration of astrocytes in scratch assay.•αA-crystallin inhibited astrocyte GFAP and neurocan expression after oxygen glucose deprivation.•αA-crystallin inhibited astrocyte BMPs mRNA expression after oxygen glucose deprivation.