Evaluation of the neurotoxic effects of engineered nanomaterials in C57BL/6J mice in 28-day oral exposure studies

•28-day neurotoxicity study in mice with foodborne TiO2 and Ag nanomaterial.•Absence of neuroinflammation, changes in spontaneous alternation and anxiety-like behavior.•Motor function changes in female mice post 28-days exposure to silver nanomaterials.•Increased tyrosine kinase activity in cortex of silver nanomaterial exposed female mice.•Persistent accumulation of silver in mouse brain up to 4 weeks post-exposure.