Effect of S-1 on blood levels of phenobarbital and phenytoin: A case report

Ken Shiraiwa,Hiroyuki Ono,Ryota Tanaka,Atsuro Fujinaga,Takahiro Hiratsuka,Ryosuke Tatsuta,Masafumi Inomata,Hiroki Itoh

CLINICAL CASE REPORTS（2021）

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摘要

Drug-drug interaction of fluorinated pyrimidine anticancer agents with phenytoin is well known, but interaction with phenobarbital is limited. We describe a case showing increases in plasma phenobarbital as well as phenytoin concentrations during preoperative S-1 (tegafur/gimeracil/oteracil) and radiation therapy for rectal cancer.

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关键词

drug-drug interaction,phenobarbital,phenytoin,S-1,therapeutic drug monitoring

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