A new perspective on the immune escape mechanism in HCC: onco-foetal reprogramming

Sin Chi Chew, Si Ying Choo,Pierce Kah-Hoe Chow

BRITISH JOURNAL OF CANCER（2021）

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摘要

Summary We found a shared immunosuppressive microenvironment between foetal liver and hepatocellular carcinoma (HCC) which includes the re-emergence of foetal-associated endothelial cells (PLVAP/VEGFR2) and foetal-like (FOLR2) tumour-associated macrophages in HCC, mediated via VEGF–NOTCH signalling. The discoveries suggest possible novel targets for therapeutic interventions in HCC.

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Cancer microenvironment,Tumour biomarkers,Biomedicine,general,Cancer Research,Epidemiology,Molecular Medicine,Oncology,Drug Resistance

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