Human gut microbial communities dictate efficacy of anti-PD-1 therapy in a humanized microbiome mouse model of glioma.

Kory J Dees,Hyunmin Koo, J Fraser Humphreys,Joseph A Hakim,David K Crossman,Michael R Crowley,L Burton Nabors,Etty N Benveniste,Casey D Morrow,Braden C McFarland

Neuro-oncology advances（2021）

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摘要

The results of our study establish the utility of humanized microbiome mice as avatars to delineate features of the host interaction with gut microbial communities needed for effective immunotherapy against GBM.

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关键词

GL261,anti-PD-1,glioblastoma,immunotherapy,microbiome

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