The expression of STAT3 inhibited the NF-ΚB signalling pathway and reduced inflammatory responses in mice with viral myocarditis

Zhihui Li, Chenqiong Wang, Yun Mao,Jieke Cui,Xi Wang, Juan Dang,Shilei Wang

International Immunopharmacology（2021）

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摘要

•STAT3 gene inhibits the NF-κB signalling pathway in VMC.•STAT3 gene reduces the inflammatory responses of VMC.•STAT3 can protect heart cells by inhibiting inflammatory responses and Th17 cell differentiation.

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关键词

STAT3,Viral myocarditis,Inflammatory responses,STAT3 conditional knockout mice,NF-κB signalling pathway

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