Circulating Pentraxin 3 In Severe Covid-19 Or Other Pulmonary Sepsis

The long pentraxin 3 (PTX3), described initially as a microvascular inflammation marker, is an acute-phase protein released by several cell types in response to infection or tissue damage. It contributes to resistance to bacteria, fungi, viruses, and inflammation regulation (1). Circulating PTX3 was abnormally high (\u003e2 ng/ml) in all 958 patients with severe sepsis or septic shock included in a pre-planned sub-study of the Albumin Italian Outcome Sepsis (ALBIOS) trial (2).