Clinical Outcome and Histological Findings After Induced Leakage of PMMA Loaded With Methotrexate and Cisplatin During Vertebroplasty: Experimental Model in Pigs.

Alvaro Silva González,Rafael Llombart-Blanco, Marcela Gallegos Angulo,Carlos Villas Tomé,Matías Alfonso Olmos-García

Global spine journal（2023）

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摘要

Massive cement leak after vertebroplasty with PMMA loaded with cisplatin is extremely toxic to the spinal cord and muscles around the spine. Therefore, its use cannot be recommended for the treatment of vertebral metastases. Using PMMA loaded with methotrexate seems to be a safe procedure, but further research is needed.

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关键词

acrylic cement,cisplatin,leakage,methotrexate,vertebroplasty

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