A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project

Chiara Pirazzini,Tiago Azevedo,Luca Baldelli, Anna Bartoletti-Stella,Giovanna Calandra-Buonaura,Alessandra Dal Molin,Giovanna Maria Dimitri,Ivan Doykov,Pilar Gómez-Garre,Sara Hägg,Jenny Hällqvist,Claire Halsband,Wendy Heywood,Silvia Jesús,Juulia Jylhävä,Katarzyna Malgorzata Kwiatkowska,Miguel A. Labrador-Espinosa, Cristina Licari,Maria Giovanna Maturo,Giacomo Mengozzi

Mechanisms of Ageing and Development（2021）

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摘要

•Several evidences suggest a continuum between ageing and Parkinson’s disease.•Propagation of inflammaging may play a major role in this process.•PROPAG-AGEING is a H2020 funded Consortium.•PROPAG-AGEING aims to characterize the contribution of ageing/inflammaging to PD.•PROPAG-AGEING envisages omic analysis of de novo PD, controls and centenarians.

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关键词

Parkinson's disease,Inflammaging,Neurodegeneration,Omics

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