Complete drying and micronization of ecamsule using supercritical CO2 as the antisolvent

Patrick Hariyanto,Aye Aye Myint,Jaehoon Kim

The Journal of Supercritical Fluids（2021）

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摘要

•SAS process using scCO2 as an antisolvent produced flake-like dry ecamsule powder.•91%-yield ecamsule microparticles with a mean diameter of 1.8 µm were produced.•Complete removal of ethanol from the SAS-dried ecamsule powder was achieved.

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关键词

Ecamsule,Micronization,Supercritical antisolvent (SAS),Hansen solubility parameters (HSPs),Particle size distribution

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