MgZnO Dual Gate Thin Film Transistor for the Sensitive Determination of Modified Folic Acid
IEEE Sensors Journal(2021)
摘要
Folate receptor (FR) is a typical tumor-associated antigen that has been widely used as a biomarker for the determination of cancer. A biosensing platform functionalized with folic acid (FA) is essential to FR detection because FA specifically binds FR. We demonstrate an MgZnO dual-gate thin-film transistor (MZO DGTFT) based biosensor for the sensitive determination of FA derivative, hexadecyl alkynated folic acid (HAFA). The receptor is an MZO nanostructure (MZO
nano
) modified sensing pad which electrically connects to the top gate of DGTFT. The bottom gate of DGTFT is used to bias the device to its optimum operation point, enabling high sensitivity. First, 11-azidoundecanoic acid (AA) was bond onto the MZO
nano
surface as the linker layer, resulting in negative charges to MZO
nano
due to carboxylic acid binding chemistry. HAFA was then immobilized on MZO
nano
via click reaction with AA. HAFA is a polar molecule with the positive end adjacent to AA/MZO
nano
, and therefore, the electrostatic condition of MZO
nano
is impacted again. Such changes were detected by DGTFT that displayed significant drain current variations. Fourier-transform infrared spectroscopy (FTIR) imaging confirms such successful chemical processes. This MZO DGTFT biosensor with HAFA is promising for potential applications in the detection of FR overexpressed cancer cells.
更多查看译文
关键词
Click chemistry,dual-gate thin film transistor,hexadecyl alkynated folic acid,magnesium zinc oxide,nanostructures
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要